Motilium Alternatives: Quick Relief When Domperidone Isn’t an Option

If you’ve tried Motilium (domperidone) and it didn’t work, or you can’t get a prescription, don’t panic. There are plenty of other drugs and home remedies that tackle nausea without the same restrictions. Below we break down the most reliable substitutes, how they compare, and when to choose each one.

Prescription meds that act like Motilium

Metoclopramide (Reglan) is probably the closest prescription rival. It speeds up stomach emptying and blocks dopamine receptors, which helps curb both vomiting and a feeling of fullness. The usual dose is 10 mg taken before meals; however, it can cause drowsiness or, rarely, movement tremors if you stay on it too long.

Ondansetron (Zofran) works a different way by blocking serotonin signals that trigger the vomiting center. It’s popular for chemotherapy‑induced nausea but also works well for everyday stomach upset. You can find it as an oral tablet, dissolvable film, or injection. Side effects are mild—mostly constipation or headache.

Prochlorperazine (Compazine) is another dopamine blocker that’s often used for severe nausea after surgery or migraines. The typical dose is 5 mg three to four times a day. It can make you feel sleepy, so avoid driving until you know how it affects you.

If you’re looking for something that doesn’t cross the blood‑brain barrier as much, Meclizine (Bonine) is an antihistamine that reduces motion sickness and vertigo. It’s taken once daily and usually only causes mild dry mouth.

Natural ways to beat nausea

When you prefer a non‑drug route, several kitchen staples can calm your stomach in minutes. Ginger—whether fresh slices, tea, or capsules—has strong anti‑emetic properties backed by clinical trials. A half‑teaspoon of grated ginger steeped in hot water works for most people.

Peppermint oil or a cup of peppermint tea relaxes the gastrointestinal muscles and can ease nausea from indigestion. Just be careful if you have acid reflux, as mint may worsen it.

Avoiding large meals, staying hydrated with small sips of water, and keeping your head elevated are simple tricks that many overlook. Eating bland foods like crackers or plain rice while waiting for medication to kick in also helps settle the stomach.

Remember, you don’t have to stick with Motilium if it’s not suitable for you. Talk to a pharmacist or doctor about these alternatives, especially if you’re on other meds that could interact. With the right choice—whether it’s a prescription swap or a ginger tea—you’ll be back to feeling normal in no time.