Periactin (Cyproheptadine) vs. Other Antihistamines: Detailed Comparison

Trying to decide whether Periactin is the right choice for your allergy or appetite‑loss needs? You’re not alone. Many people weigh the benefits of cyproheptadine against a crowded shelf of newer, often non‑sedating antihistamines. This guide breaks down what Periactin does, how it stacks up against popular alternatives, and which factors should tip the scale in your favor.

Periactin is a first‑generation antihistamine whose generic name is cyproheptadine. It blocks histamine receptors and also antagonises serotonin, which gives it a unique appetite‑stimulating effect. Approved in Australia for allergic rhinitis, itching, and severe loss of appetite, Periactin has been on the market since the 1960s.

While newer antihistamines tend to promise less drowsiness, Periactin’s dual action can be a real advantage for patients who need both allergy relief and a boost in calorie intake. Below we compare it head‑to‑head with four common alternatives: Cetirizine, Loratadine, Diphenhydramine, and Hydroxyzine.